Prematurity in Gene Therapy

Recent Advances in Hemophilia Gene Therapy

Heterogeneous loss of function mutations at F8 and F9 genes causes X-linked recessive bleeding disorders, hemophilia A (HA) and hemophilia B (HB), respectively. HA is clinically indistinguishable from HB and accounts for more than 80% of hemophilia cases; the former affects 1/5000 and the latter 1/25000 male births worldwide. In Iran, it is estimated that around 4300 HA and 900 HB patients are ...

Caffeine therapy for apnea of prematurity.

BACKGROUND Methylxanthines reduce the frequency of apnea of prematurity and the need for mechanical ventilation during the first seven days of therapy. It is uncertain whether methylxanthines have other short- and long-term benefits or risks in infants with very low birth weight. METHODS We randomly assigned 2006 infants with birth weights of 500 to 1250 g during the first 10 days of life to ...

ژن درمانی Gene Therapy

Gene therapy for retinopathy of prematurity: the eye is a window to the future.

The eye is the window to the brain, the soul, and now perhaps even the future, with the exciting publication by Chowers et al in this month’s issue of the BJO (p 991). The authors give us a view of the future as they elegantly demonstrate that gene transfer into blood vessels is possible in a rat model of retinopathy of prematurity (ROP). The future may be close at hand, because the eye once ag...

Survey of Related Factors in Prematurity Birth

ABSTRACT Numerous factors have been implicated as determinants of prematurity and low birth weight, including maternal diseases, placenta insufficiency, uterous abnormality, maternal addiction, prenatal care and etc. To determinant of prematurity in Gorgan city, we studied 450 neonates was borned in Dezyani hospital during six months (winter 1998 until spring 1999) and divided them into two...